INVOINNOVATION + NEW VENTURES

POP3 protein as a method to modulate inflammation.

New antibacterial compounds targeting bacterial nitric oxide synthase show promise against resistant bacterial strains

A novel mechanism to help guide arrested oocytes through meiotic division.

Treatment for atrial fibrillation (AF) by modulation of nerves in the heart muscle using inhibitors of G protein signaling

Novel strategy to compromise the metabolism of myeloma cells and induce tumor regression in multiple myeloma (MM) patients

Novel approach to treating multiple myeloma and other cancers using existing therapeutics.

Novel compound that inhibits nitric oxide synthase, a key oxidative stress mediator in human melanoma

Novel material for hydrogel wound dressings that can incorporate therapeutic metal ions

New approach targeting drusen accumulation for treatment and prevention of age-related macular degeneration.

A validated novel compound and medicinal chemistry refinement for bioavailable small molecule inhibitors of protein kinases or protein kinase-mediated cellular stress response pathways

Development of a new class of small molecule therapeutic candidates with potential to address areas of disease and injury relevant to tissue barrier dysfunction

A portfolio of neuronal nitric oxide synthase inhibitors for use in treating neurodegenerative disorders.

Pro-drug antibiotic candidates for the treatment of penicillin-resistant Streptococcus pneumoniae infections

Polymer-based drug delivery system that activates scar-free tissue regeneration 

An unbiased library of compounds was generated using a one-step method in order to screen for covalent inhibitors of enzymes

Selective human sirtuin-2 inhibitors for use in treating Huntington's disease

Gene therapy approach for inhibiting fibrosis of cardiac tissue

Novel citrate-based thermoresponsive gel dressing that fosters cell adhesion to improve wound healing

Researchers at Northwestern University have developed a function blocking monoclonal antibody (mAb) to thea4 subunit of laminin.

A Novel Class of Heterotricyclic AMPA Receptor Antagonists for Treatment of Epilepsy, Pain and Other Neurological Diseases

Northwestern researchers have identified a lead compound that can enhance immune function in vivo through a novel mechanism of stabilizing the CD154 trimer on the surface of activated T cells.

Novel Ornithine Aminotransferase Inhibitor for potential new treatment for hepatocellular carcinoma

A new class of small molecules that may be used to target specific AMPA* receptors

Enzymatic digestion composition to remove atherosclerotic plaque without surgery or other invasive procedures.

Discovery of compositions and development of methods for modulating EBV infection in patients.

Novel small molecule that boosts the innate immune response against viral infection

Compositions and methods to manipulate ion channels to decrease pathophysiological high frequency neuronal bursts of Parkinson's and related diseases

New approach for treating AMKL by inducing polyploidization to revert cancerous cells into normal cells

A novel class of small molecules that can reactivate mutant p53 leading to apoptosis in cancer cells.

Synthesis of a novel family of peptide compounds with increased anti-proliferative activity

PEDF, a novel therapeutic agent for cancer treatment.

Discovery of ALS compounds that decrease SOD1 expression with diminished toxic side effects.

Novel Ornithine Aminotransferase Inhibitor for potential new treatment for hepatocellular carcinoma

A multimaterial bio-ink for 3D printing of cross-linked, soft hydrogels that can be used in tissue engineering

Novel therapeutic and diagnostic agents targeting the Nodal and Notch4 pathway in cancer stem cells.

Systemic and Topical Treatment of Wounds with Inhibitors of Glucosylceramide Synthase; Any Use of these Compounds in Topical Formulation

A novel method to treat urinary tract infection using attenuated-live vaccines.

A non-human primate model for regenerating the bladder using adult stem cells.

Novel strategy to improve gene silencing by RNAi  for development of therapeutics

Novel gene therapy for atrial fibrillation (AF) targeting molecular mechanisms underlying disease development

POP3 protein as a method to modulate inflammation.

A family of pyridazine compounds that modulate intracranial inflammatory responses following CNS insults such as diverse pathogenic stimuli, physical force trauma, brain hemorrhage, or complications of major surgeries

Small portion of maspin protein has been developed into an inhibitor of angiogenesis for the purposes of cancer treatment

Improved lipid-based co-encapsulation technology for delivery of active arsenic and platinum compounds.

Potent and selective antagonists of the Cav 1.3 calcium channel with neuroprotective potential

Novel ability to encapsulate arsenic compounds and target their release for therapeutic applications

Microbial modulation of immunity and pain resulting from urinary tract infection.

Novel bacterial strain for research of chronic pelvic pain (CPP)

Potent and non toxic cancer therapeutic compounds that have been isolated from sea cucumbers

A novel fiber formulation, made with natural pectin, which is tasty and practical to use as a dietary supplement

Development of a gadolinium(III)-nanodiamond complex that, in a series of tests, demonstrates a significant increase in relaxivity and, in turn, a significant increase in contrast enhancement in imaging.

Very low dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T-cell subsets in a mouse model with potential human applications.

The Use of HMG-CoA Reductase Inhibitors (Statins) to Reduce Hypertrophic Scar Formation

Use of Proteasome Inhibitors for Sensitization of Patients to Glucocorticoids and Selective Activators of the Glucocorticoid Receptor (SEGRA)

Lead Compounds For Neurodegeneration and Neuroinflammation

New method for modulating activity of dopaminergic neurons to alleviate symptoms of Parkinson's disease